Relation of vitamin D deficiency and new-onset atrial fibrillation among hypertensive patients

Ozcan O. U., Gurlek A., Gursoy E., GEREDE ULUDAĞ D. M., EROL Ç.

JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION, cilt.9, sa.4, ss.307-312, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.jash.2015.01.009
  • Dergi Adı: JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.307-312
  • Anahtar Kelimeler: Arrhythmia, case-control study, nutrition, renin-angiotensin-aldosterone system, ARTERIAL-HYPERTENSION, ANGIOTENSIN SYSTEM, INHIBITION, RISK
  • Ankara Üniversitesi Adresli: Evet

Özet

Vitamin D deficiency is associated with various cardiovascular disorders including hypertension, coronary artery disease, and heart failure. The renin-angiotensin-aldosterone system (RAS) axis is activated in vitamin D deficiency. The RAS axis also plays a role in the pathophysiology of atrial fibrillation (AF). We aimed to investigate whether vitamin D deficiency is a risk factor for the development of new-onset AF in hypertension. A total of 227 hypertensive patients were enrolled, of whom 137 had new-onset AF; 90 patients without AF were included in the control group. The age of the patient, left atrial diameter, and vitamin D deficiency increased the probability of new-onset AF independent from confounding factors (odds ratio [On 1.04; 95% confidence interval [CI] 1.01-1.08; P = .03 for age; OR, 1.88; 95% CI, 1.15-3.45; P = .03 for left atrial diameter; OR, 1.68; 95% CI, 1.18-2.64; P = .03 for vitamin D deficiency). Vitamin D deficiency is associated with new-onset AF in hypertension. (C) 2015 American Society of Hypertension. All rights reserved.