Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Journal of Medical Sciences, cilt.40, sa.1, ss.1-9, 2020 (SCI-Expanded)
© 2020 by Türkiye Klinikleri.Objective: One-hour plasma glucose level ≥155 mg/dL in the oral glucose tolerance test (OGTT) in adults increases the risk of diabetes, dyslipidemia, cardiovascular disease and non-alcoholic fatty liver disease. Studies in children are limited and in our study, the relationship between the one-hour plasma glucose elevation and metabolic parameters was investigated in children with normal glucose tolerance (NGT). Material and Methods: 143 overweight/obese children who were 9-18 years old with NGT result (fasting plasma glucose <100 mg/dL and 2nd hour glucose concentration <140 mg/dL in OGTT) were evaluated retrospectively. The group with 1st hour glucose concentration of <155 mg/dL was grouped Group 1 and the group with 1st hour glucose concentration of ≥155 mg/dL was grouped Group 2. Results: One-hour glucose level was positively correlated with triglyceride, ALT, HbA1c, HOMA-IR and negatively correlated with HDL (p<0.05). The ratio of males in Group 2 (53.1%) was more frequent than in Group 1 (30.6%) (p:0.019). In Group 2 systolic, diastolic blood pressure, HbA1c, fasting insulin, triglyceride, ALT were significantly higher, and HDL levels were lower (p<0.05). In Group 2 HOMA-IR level was higher, whole-body insulin sensitivity index (WBISI) and disposition index (DI) were significantly lower (p<0.05). In Group 2 the ratio of non-alcoholic fatty liver disease was more frequent (p: 0.001). Conclusion: Our study is the first study to found the relationship between level of 1st hour plasma glucose and non-alcoholic fatty liver disease in children and adolescents. One-hour plasma glucose level in children and adolescents is an important and early marker of insulin resistance, prediabetes and non-alcoholic fatty liver disease.