Assessment of cytogenetic aberrations and comet assay in colorectal adenocarcinomas

Baltaci V., Sardas S., Aytac B., Cakar S., Karakaya A.

TUMORI, cilt.89, sa.3, ss.305-310, 2003 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 89 Sayı: 3
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1177/030089160308900314
  • Dergi Adı: TUMORI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.305-310
  • Anahtar Kelimeler: colorectal adenocarcinoma, comet assay, chromosomal aberration, DNA damage, DNA DAMAGE, CELLS, IDENTIFICATION, FEATURES, CANCERS, TUMOR
  • Ankara Üniversitesi Adresli: Hayır

Özet

Aims, background and study design: Few studies have investigated the karyotypes of colorectal carcinomas with emphasis on the correlation between cytogenetic findings and clinicopathologic features. The aim of our study involving 20 colorectal adenocarcinomas was to determine their genomic alterations at the chromosomal level by correlating the cytogenetic findings with the extent of DNA damage and clinicopathologic parameters and to compare the results with those of healthy controls.