Preparation of Chitosan and Glycol Chitosan Coated Magnetic Nanoparticles Loaded with Carboplatin as Anticancer Drug

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ATİLA DİNÇER C., Erdek A. M., KARAKEÇİLİ A., YILDIZ N.

JOURNAL OF POLYTECHNIC-POLITEKNIK DERGISI, cilt.22, sa.4, ss.1017-1022, 2019 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2339/politeknik.501694
  • Dergi Adı: JOURNAL OF POLYTECHNIC-POLITEKNIK DERGISI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1017-1022
  • Anahtar Kelimeler: Fe3O4-OA nanoparticles, chitosan / glycol chitosan coating, carboplatin, anticancer drug loading, drug release, IRON-OXIDE NANOPARTICLES, FE3O4 NANOPARTICLES, TARGETED DELIVERY
  • Ankara Üniversitesi Adresli: Evet

Özet

Surface modified Fe3O4 nanoparticles ( Fe3O4-OA) with an average diameter of 10 nm were synthesized, coated by chitosan (CS) and glycol chitosan (GCS), thus magnetic polymer nanocomposites were obtained. The magnetic nanostructures were analyzed by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), X-Ray diffraction (XRD) and vibrating sample magnetometer (VSM). All magnetic structures synthesized in this study exhibited superparamagnetic properties. Loading carboplatin (CPt) as anticancer drug to Fe3O4-OA-GCS nanocomposites were carried out with 13.17 % drug content and 38 % encapsulation efficiency. The cytotoxicity studies were occured by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on L929 mouse fibroblasts and MCF-7 human breast cancer cells. Fe3O4-OA-GCS-CPt nanocomposites showed higher cytotoxicity than free CPt on the MCF-7 cells at 50 mu g/ml drug concentrations during 72 h.