Aglepristone and cloprostenol combination in the termination of late-term pregnancy in queens

Alkan K. K., ALKAN H., Tez G., KANCA H.

JOURNAL OF FELINE MEDICINE AND SURGERY, cilt.22, sa.10, ss.907-915, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 10
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1177/1098612x19892087
  • Dergi Adı: JOURNAL OF FELINE MEDICINE AND SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.907-915
  • Anahtar Kelimeler: Aglepristone, cloprostenol, pregnancy termination, progesterone, CORPUS-LUTEUM, DOMESTIC CAT, PROGESTERONE, PARTURITION, INDUCTION, ABORTION, GESTATION, ANTAGONIST, MORTALITY, CERVIX
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives Termination rates for the highly recommended aglepristone (AGL) treatment are low in late-term pregnancy in queens. We studied the effects of an AGL and cloprostenol (CLO) combination in the termination of late-term pregnancy. Methods Pregnant queens were assigned to two groups. Queens in the AGL group (n = 10) received AGL 10 mg/kg, twice, 24 h apart. Queens in the AGL-CLO group (n = 9) were additionally injected with a single dose of CLO (5 mu g/kg) 24 h after the second dose of AGL. Progesterone, 17beta(beta)-oestradiol, cortisol, oxytocin and prostaglandin F2alpha (PGF2 alpha) metabolite were measured in sera obtained at days 0, 1 and 2, and on the day of abortion. Results Average gestational age in both groups was similar (AGL 38.61 +/- 0.91 days vs AGL-CLO 39.39 +/- 1.35 days; P >0.05). Termination rates were 80% and 100% in the AGL and AGL-CLO groups, respectively (P <0.05). Fetal expulsion time was significantly longer (P <0.001) in the AGL group (96.9 +/- 6 h) compared with the AGL-CLO group (69.8 +/- 3.3 h). Duration of abortion was 19.8 +/- 2.6 h and 12.6 +/- 1.4 h in the AGL and AGL-CLO groups, respectively (P <0.05). Both treatments were well tolerated. Significantly (P <0.05) lower serum progesterone concentrations were observed in both groups at the day of abortion and concentrations in the AGL-CLO group (4.19 +/- 0.80 ng/ml) were lower than in the AGL group (9.89 +/- 2.21 ng/ml; P <0.05). Conclusions and relevance AGL and CLO combination increases pregnancy termination rate in late-term pregnant queens. In addition, CLO contributes to a decrease in luteal function in AGL-treated late-term pregnant queens.