Therapeutic evaluation of interleukin 1-beta antagonist Anakinra against traumatic brain injury in rats

Hasturk, Askin; Yilmaz, Erdal; Turkoglu, Erhan; Kertmen, Hayri; Horasanli, Bahriye; Hayirli, Nazli; Erguder, BERRİN; EVİRGEN, OYA

doi:10.5505/tjtes.2015.57894

Therapeutic evaluation of interleukin 1-beta antagonist Anakinra against traumatic brain injury in rats

Hasturk A. E., Yilmaz E. R., Turkoglu E., Kertmen H., Horasanli B., Hayirli N., ...More

ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, vol.21, no.1, pp.1-8, 2015 (SCI-Expanded, Scopus, TRDizin)

Publication Type: Article / Article
Volume: 21 Issue: 1
Publication Date: 2015
Doi Number: 10.5505/tjtes.2015.57894
Journal Name: ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Page Numbers: pp.1-8
Keywords: Antioxidant, anakinra, interleukin-1, neuroprotection, traumatic brain injury, LIPID-PEROXIDATION, NEUROPROTECTION, EXPRESSION, DISEASE
Open Archive Collection: AVESIS Open Access Collection
Ankara University Affiliated: Yes

Abstract

BACKGROUND: The aim of this study was to evaluate the therapeutic efficiency of Anakinra, an IL-1 beta antagonist with anti-inflammatory effects, in an experimental model of traumatic brain injury (TBI).