Laryngeal dysplasia: Relationship between anterior commissure involvement and progression to invasive cancer

Karakaya Gojayev E., Büyükatalay Yaldlz Z. Ç., DURSUN G., Gökcan K.

Journal of Laryngology and Otology, cilt.139, sa.10, ss.923-927, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 139 Sayı: 10
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1017/s0022215125102521
  • Dergi Adı: Journal of Laryngology and Otology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, MLA - Modern Language Association Database, Veterinary Science Database
  • Sayfa Sayıları: ss.923-927
  • Anahtar Kelimeler: cancer, chemoradiotherapy, dysphonia, larynx, voice
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives Laryngeal dysplasia is a pre-cancerous lesion within the larynx. This study aims to identify factors influencing progression to cancer by analysing long-term follow-up data. Methods Data from 221 patients diagnosed between 2005 and 2017 were reviewed retrospectively. Patient demographics, treatment strategies and follow-up results were compared. Results Progression to cancer occurred in 26 patients (11.7 per cent). A significant association was found between cancer progression and initial biopsies obtained from the anterior commissure (34.6 per cent in progressing cases vs. 6.2 per cent in non-progressing; p < 0.001). Carcinoma in situ cases showed a higher progression rate (21.7%) compared to mild dysplasia (3.4 per cent) (p = 0.007). The group with cancer progression also had higher rates of other cancers (15.4 per cent vs. 2.1 per cent; p = 0.008), including lung cancer (11.5 per cent vs. 0 per cent; p = 0.001). Conclusion The study determined an 11.7 per cent progression rate of laryngeal dysplasia to cancer. Lesions involving the anterior commissure carried an approximately 8.1-fold increased risk of progression.