Cytokine polymorphisms in silicosis and other pneumoconioses

Yucesoy B., Vallyathan V., Landsittel D., Simeonova P., Luster M.

MOLECULAR AND CELLULAR BIOCHEMISTRY, vol.234, no.1, pp.219-224, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 234 Issue: 1
  • Publication Date: 2002
  • Doi Number: 10.1023/a:1015987007360
  • Journal Name: MOLECULAR AND CELLULAR BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.219-224
  • Keywords: silicosis, pneumoconiosis, cytokines, polymorphism, TNF-alpha, TUMOR-NECROSIS-FACTOR, MAJOR HISTOCOMPATIBILITY COMPLEX, FACTOR-ALPHA GENE, IL-1 RECEPTOR ANTAGONIST, TNF-ALPHA, PROMOTER POLYMORPHISM, SEVERITY FACTOR, COAL-MINERS, INTERLEUKIN-1, ASSOCIATION
  • Ankara University Affiliated: No

Abstract

Silicosis and coal workers' pneumoconiosis are complex multifactorial lung diseases whose etiopathogenesis are not well defined. It is generally accepted that fibrotic lung disorders are mediated by macrophage-derived cytokines and growth factors. There is evidence showing a crucial role for tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) in inflammation caused by silica dust and in the transition from simple to progressive massive fibrosis. In this review we discuss genetic polymorphisms responsible for regulating the production of these proinflammatory cytokines and their role in modifying silicosis severity.