Cytokine polymorphisms in silicosis and other pneumoconioses

Yucesoy B., Vallyathan V., Landsittel D., Simeonova P., Luster M.

MOLECULAR AND CELLULAR BIOCHEMISTRY, cilt.234, sa.1, ss.219-224, 2002 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 234 Sayı: 1
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1023/a:1015987007360
  • Dergi Adı: MOLECULAR AND CELLULAR BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.219-224
  • Anahtar Kelimeler: silicosis, pneumoconiosis, cytokines, polymorphism, TNF-alpha, TUMOR-NECROSIS-FACTOR, MAJOR HISTOCOMPATIBILITY COMPLEX, FACTOR-ALPHA GENE, IL-1 RECEPTOR ANTAGONIST, TNF-ALPHA, PROMOTER POLYMORPHISM, SEVERITY FACTOR, COAL-MINERS, INTERLEUKIN-1, ASSOCIATION
  • Ankara Üniversitesi Adresli: Hayır

Özet

Silicosis and coal workers' pneumoconiosis are complex multifactorial lung diseases whose etiopathogenesis are not well defined. It is generally accepted that fibrotic lung disorders are mediated by macrophage-derived cytokines and growth factors. There is evidence showing a crucial role for tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) in inflammation caused by silica dust and in the transition from simple to progressive massive fibrosis. In this review we discuss genetic polymorphisms responsible for regulating the production of these proinflammatory cytokines and their role in modifying silicosis severity.