Relationship Between Functional Promoter Polymorphism in the XBP1 Gene (-116C/G) and Obesity

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YILMAZ E., BERBEROĞLU M., Akar N.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, cilt.16, sa.1, ss.99-102, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1177/1076029608323498
  • Dergi Adı: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.99-102
  • Anahtar Kelimeler: endoplasmic reticulum stress, XBP1, obesity, ENDOPLASMIC-RETICULUM STRESS, UNFOLDED PROTEIN RESPONSE, ER STRESS, DIABETES-MELLITUS, MESSENGER-RNA, IRE1, KINASE, RISK, SCHIZOPHRENIA, INFLAMMATION
  • Ankara Üniversitesi Adresli: Evet

Özet

Endoplasmic reticulum stress is a central feature of obesity, insulin resistance, and type 2 diabetes. A polymorphism of the XBP1 gene (-116C/G), a transcription factor that modulates the endoplasmic reticulum stress response, Causes an impairment of its positive feedback system. The authors examined a role of the polymorphism in the development of obesity. The polymorphism was investigated in clinically obese children and compared with controls. Significant difference of genotype distribution was observed, which suggested that the -116C/G genotype may be a risk factor for at least pediatric obesity.