Subarachnoid transplantation of autologous neurogenically induced bone marrow derived mesenchymal stem cells for the treatment of fibrocartilaginous embolic myelopathy in two dogs

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Can P., Beşaltı Ö., Akpinar E., Aktas Z., Elçin A. E., Elçin Y. M.

TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES, cilt.40, sa.1, ss.120-123, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3906/vet-1506-21
  • Dergi Adı: TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.120-123
  • Anahtar Kelimeler: Dog, subarachnoid transplantation, mesenchymal stem cells, CLINICAL FINDINGS, RECOVERY
  • Ankara Üniversitesi Adresli: Evet

Özet

The objective of this study was to investigate the effects of autologous neurogenically induced bone marrow-derived mesenchymal stem cells (NIBM-MSCs) in two dogs suspected to have fibrocartilaginous embolic myelopathy FCEM). Both dogs were paraplegic without deep pain perception DPP) and tentatively diagnosed by MRI. Autologous NIBM-MSCs (5 x 10(6)) were transplanted into the lumbar subarachnoid space two times with a 21-day interval for each patient. Based on a 21-month follow-up of the treated animals, the transplantation of NIBM-MSCs seems to be promising in subjects with FCEM lacking DPP.