Subarachnoid transplantation of autologous neurogenically induced bone marrow derived mesenchymal stem cells for the treatment of fibrocartilaginous embolic myelopathy in two dogs

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Can P., Beşaltı Ö., Akpinar E., Aktas Z., Elçin A. E., Elçin Y. M.

TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES, vol.40, no.1, pp.120-123, 2016 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.3906/vet-1506-21
  • Journal Name: TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.120-123
  • Keywords: Dog, subarachnoid transplantation, mesenchymal stem cells, CLINICAL FINDINGS, RECOVERY
  • Open Archive Collection: AVESIS Open Access Collection
  • Ankara University Affiliated: Yes

Abstract

The objective of this study was to investigate the effects of autologous neurogenically induced bone marrow-derived mesenchymal stem cells (NIBM-MSCs) in two dogs suspected to have fibrocartilaginous embolic myelopathy FCEM). Both dogs were paraplegic without deep pain perception DPP) and tentatively diagnosed by MRI. Autologous NIBM-MSCs (5 x 10(6)) were transplanted into the lumbar subarachnoid space two times with a 21-day interval for each patient. Based on a 21-month follow-up of the treated animals, the transplantation of NIBM-MSCs seems to be promising in subjects with FCEM lacking DPP.