Intramyocardial Transplantation of Umbilical Cord Mesenchymal Stromal Cells in Chronic Ischemic Cardiomyopathy: A Controlled, Randomized Clinical Trial (HUC-HEART Trial
INTERNATIONAL JOURNAL OF STEM CELLS, cilt.13, sa.3, ss.364-376, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13 Sayı: 3
- Basım Tarihi: 2020
- Doi Numarası: 10.15283/ijsc20075
- Dergi Adı: INTERNATIONAL JOURNAL OF STEM CELLS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE
- Sayfa Sayıları: ss.364-376
- Anahtar Kelimeler: Bone marrow MSC, Clinical trial, Ischemic cardiomyopathy, Stem cell therapy, Umbilical cord MSC, STEM-CELLS, INTRACORONARY INFUSION, HEART-FAILURE, PHASE 1/2, REGENERATION, PERFUSION, EFFICACY, SAFETY
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Üniversitesi Adresli: Evet
Özet
Background and Objectives: The HUG-HEART Trial (ClinicalTrials.gov Identifier: NCT02323477) was a controlled, prospective, phase VII, multicenter, single-blind, three-arm randomized study of intramyocardial deliver of human umbilical cord-derived mesenchymal stromal cells (HUC-MSCs) combined with coronary artery bypass-grafting (CABG) n patients with chronic ischemic cardiomyopathy (CIC). The trial aimed to assess (i) the safety and the efficacy of cell transplantation during one-year follow-up, (ii) to compare the efficacy of HUC-MSCs with autologous bone-marrow-derived mononuclear cells (BM-MNCs) in the same clinical settings.