Comparative effects of methylprednisolone and tetracosactide (ACTH(1-24)) on ischemia/reperfusion injury of the rabbit spinal cord

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Kertmen H., Celikoglu E., Ozturk O. C., Gurer B., Bozkurt H., Kanat M. A., ...Daha Fazla

ARCHIVES OF MEDICAL SCIENCE, cilt.14, sa.6, ss.1459-1470, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5114/aoms.2017.65650
  • Dergi Adı: ARCHIVES OF MEDICAL SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1459-1470
  • Anahtar Kelimeler: adrenocorticotropic hormone, ischemia-reperfusion, methylprednisolone, neuroprotection, spinal cord, tetracosactide, ISCHEMIA-REPERFUSION INJURY, LIPID-PEROXIDATION, MELANOCORTIN PEPTIDES, XANTHINE-OXIDASE, PARAPLEGIA, EXPRESSION, AGONIST, INFLAMMATION, INHIBITION, RECEPTORS
  • Ankara Üniversitesi Adresli: Evet

Özet

Introduction: Tetracosactide is an engineered peptide that applies the same biological impacts as the endogenous adrenocorticotropic hormone. Previous studies indicated that tetracosactide has anti-inflammatory, antioxidant and neurotrophic activity. In this study, we hypothesized that tetracosactide may have protective effects in spinal cord ischemia-reperfusion injury.