Cardiac arrest due to a fatal dose of propranolol successfully treated with intravenous lipid infusion

Botan E., KENDİRLİ T., Gun E., Balsak S., RAMOĞLU M. G., Tutar E.

TURKISH JOURNAL OF PEDIATRICS, vol.63, no.5, pp.913-916, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 5
  • Publication Date: 2021
  • Doi Number: 10.24953/turkjped.2021.05.020
  • Journal Name: TURKISH JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.913-916
  • Keywords: beta blockers, poisoning, propranolol, children, intravenous lipid infusion therapy, BLOCKER
  • Ankara University Affiliated: Yes

Abstract

Background. Beta blockers (BB) are used for very different indications in both adults and children. There can be mild adverse effects with normal doses. When taken in toxic doses, this can have fatal results in children. There are some standard therapies during BB poisoning such as insulin and glucagon but there is not enough knowledge concerning intravenous lipid infusion therapy (ILI). Case. Herein we present a case of propranolol poisoning in a previously healthy 2-year-old girl. In this patient, cardiac arrest developed twice, and cardiopulmonary resuscitation was performed for 5 and 20 minutes, respectively. We initiated inotropes, insulin, calcium and glucagon with a lack of response to all medical treatment. We used ILI and the patient improved after this treatment. She recovered without any disability. Conclusions. ILI treatment should be considered with life-threatening BB poisoning which is unresponsive to standard therapies.