Rapid and accurate simultaneous determination of fosinopril sodium and hydrochlorothiazide in tablets by HPLC

Ozkan, SİBEL; Akay, C; Cevheroglu, S; Senturk, Z

doi:10.1081/jlc-100103424

Rapid and accurate simultaneous determination of fosinopril sodium and hydrochlorothiazide in tablets by HPLC

Atıf İçin Kopyala

Ozkan S. A., Akay C., Cevheroglu S., Senturk Z.

Journal of Liquid Chromatography and Related Technologies, cilt.24, sa.7, ss.983-991, 2001 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 24 Sayı: 7
Basım Tarihi: 2001
Doi Numarası: 10.1081/jlc-100103424
Dergi Adı: Journal of Liquid Chromatography and Related Technologies
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.983-991
Ankara Üniversitesi Adresli: Evet

Özet

A new, simple, precise, accurate, and rapid reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of fosinopril sodium and hydrochlorothiazide from tablets. The procedure is based on the use of the RP-HPLC method with a UV detector. Each analysis requires no longer than 6 minutes. A reversed phase C18 column with a mobile phase composed of a mixture of methanol: water (40:60, v/v), adjusted to pH 4 with 10% orthophosphoric acid, was used to separate both compounds with.