Intramesenteric steroid treatment for steroid-refractory gastrointestinal graft versus host disease Steroid dirençli gastrointestinal graft versus host hastalıǧında intramezenterik steroid uygulaması

Bilgin A. U., TOPÇUOĞLU P., Sancak T., Konuk N., Arat M.

Turkish Journal of Hematology, cilt.29, sa.4, ss.409-412, 2012 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5505/tjh.2012.57855
  • Dergi Adı: Turkish Journal of Hematology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.409-412
  • Anahtar Kelimeler: Intramesenteric steroid, Steroid-refractory GVHD
  • Ankara Üniversitesi Adresli: Evet

Özet

Currently, steroid-refractory severe gastrointestinal (GI) graft versus host disease (GVHD) is among the most important complications of allogeneic transplantation, and as yet there is no standard approach to its treatment. Herein we report two cases with steroid-refractory GI GVHD that received intramesenteric steroid treatment. In both cases the frequency and volume of diarrhea resolved completely following intramesenteric methylprednisolone (MP) injection. In conclusion, intra-arterial steroid injection might be an alternative treatment approach for steroid-refractory GI GVHD.