Effects of clopidogrel on survival of rat skin flaps

Ersoy A., Sevin K., Sevin A., Serel S.

JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, cilt.60, sa.8, ss.861-863, 2007 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.bjps.2007.02.001
  • Dergi Adı: JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.861-863
  • Anahtar Kelimeler: clopidogrel, rat skin flap, flap survival, HIGH-DOSE ASPIRIN, DELAY PHENOMENON, MODEL, THROMBOSIS
  • Ankara Üniversitesi Adresli: Hayır

Özet

Clopidogrel is a thienopyridine derivative that is chemically related to ticlopidine, which irreversibly inhibits platelet aggregation by selectively binding to adenylate cyclase-coupled adenosine diphosphate receptors on the platelet's surface. In animal models, clopidogrel has been shown to reduce the incidence of both arterial and venous thrombi. In the present study the effects of clopidogrel on the survival of rat epigastric island flaps was researched. Epigastric island flaps of 7 x 7 cm were raised from symphisis pubis to arcus costa with the panniculus carnosus. The experimental group received seven doses of 25 mg/kg clopidogrel postoperatively, the first dose given immediately after the suturing of the flaps. The rats were anaesthetised on postoperative day 7 to assess the survival of flaps.