NMDA receptor blockage with 2-amino-5-phosphonovaleric acid improves oxidative stress after spinal cord trauma in rats

Vural, M.; Arslantas, A.; YAZIHAN, NURAY; Koken, T.; UZUNER, KUBİLAY; Arslantas, D.; Ozbek, Z.

doi:10.1038/sc.2009.100

NMDA receptor blockage with 2-amino-5-phosphonovaleric acid improves oxidative stress after spinal cord trauma in rats

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Vural M., Arslantas A., YAZIHAN N., Koken T., UZUNER K., Arslantas D., ...More

SPINAL CORD, vol.48, no.4, pp.285-289, 2010 (SCI-Expanded)

Publication Type: Article / Article
Volume: 48 Issue: 4
Publication Date: 2010
Doi Number: 10.1038/sc.2009.100
Journal Name: SPINAL CORD
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.285-289
Keywords: experimental spinal cord injury, 2-amino-5-phosphonovaleric acid (APV), NMDA receptor blocker, oxidative stress, GSH, MDA, MITOCHONDRIAL-FUNCTION, SUPEROXIDE-DISMUTASE, INJURY, GLUTAMATE, ANTAGONIST, APOPTOSIS, ISCHEMIA, DAMAGE
Ankara University Affiliated: Yes

Abstract

Study design: 2-amino-5-phosphonovaleric acid (APV) is an N-methyl-D-aspartate (NMDA) receptor blocker and has neuroprotective properties. This study is aimed at evaluating the effect of APV treatment on oxidative status after spinal cord injury (SCI).