NMDA receptor blockage with 2-amino-5-phosphonovaleric acid improves oxidative stress after spinal cord trauma in rats

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Vural M., Arslantas A., YAZIHAN N., Koken T., UZUNER K., Arslantas D., ...Daha Fazla

SPINAL CORD, cilt.48, sa.4, ss.285-289, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 4
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1038/sc.2009.100
  • Dergi Adı: SPINAL CORD
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.285-289
  • Anahtar Kelimeler: experimental spinal cord injury, 2-amino-5-phosphonovaleric acid (APV), NMDA receptor blocker, oxidative stress, GSH, MDA, MITOCHONDRIAL-FUNCTION, SUPEROXIDE-DISMUTASE, INJURY, GLUTAMATE, ANTAGONIST, APOPTOSIS, ISCHEMIA, DAMAGE
  • Ankara Üniversitesi Adresli: Evet

Özet

Study design: 2-amino-5-phosphonovaleric acid (APV) is an N-methyl-D-aspartate (NMDA) receptor blocker and has neuroprotective properties. This study is aimed at evaluating the effect of APV treatment on oxidative status after spinal cord injury (SCI).