BCG vaccination in patients with severe combined immunodeficiency: Complications, risks, and vaccination policies

Marciano, Beatriz; Huang, Chiung-Yu; Joshi, Gyan; Rezaei, Nima; Carvalho, Beatriz; Allwood, Zoe; İKİNCİOĞULLARI, KAMİLE; Reda, Shereen; Gennery, Andrew; Thon, Vojtech; Espinosa-Rosales, Francisco; Al-Herz, Waleed; Porras, Oscar; Shcherbina, Anna; Szaflarska, Anna; Kilic, Sebnem; Franco, Jose; Gomez Raccio, Andrea; Roxo, Persio; Esteves, Isabel; Galal, Nermeen; Grumach, Anete; Al-Tamemi, Salem; YILDIRAN, ALİŞAN; Orellana, Julio; Yamada, Masafumi; Morio, Tomohiro; Liberatore, Diana; Ohtsuka, Yoshitoshi; Lau, Yu-Lung; Nishikomori, Ryuta; Torres-Lozano, Carlos; Mazzucchelli, Juliana; Vilela, Maria; Tavares, Fabiola; Cunha, Luciana; Pinto, Jorge; Espinosa-Padilla, Sara; Hernandez-Nieto, Leticia; Elfeky, Reem; Ariga, Tadashi; Toshio, Heike; DOĞU, ESİN; Cipe, Funda; Formankova, Renata; Enriqueta Nunez-Nunez, M.; Bezrodnik, Liliana; Marques, Jose; Pereira, Maria; Listello, Viviana; Slatter, Mary; Nademi, Zohreh; Kowalczyk, Danuta; Fleisher, Thomas; Davies, Graham; Neven, Benedicte; Rosenzweig, Sergio

doi:10.1016/j.jaci.2014.02.028

BCG vaccination in patients with severe combined immunodeficiency: Complications, risks, and vaccination policies

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Marciano B. E., Huang C., Joshi G., Rezaei N., Carvalho B. C., Allwood Z., ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.133, no.4, pp.1134-1141, 2014 (SCI-Expanded)

Publication Type: Article / Article
Volume: 133 Issue: 4
Publication Date: 2014
Doi Number: 10.1016/j.jaci.2014.02.028
Journal Name: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1134-1141
Keywords: Primary immunodeficiency, severe combined immunodeficiency, vaccine, BCG, mycobacteria, newborn screening, hematopoietic stem cell transplant, immune reconstitution syndrome, BACILLUS-CALMETTE-GUERIN, CENTRAL-NERVOUS-SYSTEM, IMMUNOCOMPROMISED CHILDREN, TUBERCULOUS MENINGITIS, VACCINES
Ankara University Affiliated: Yes

Abstract

Background: Severe combined immunodeficiency (SCID) is a syndrome characterized by profound T-cell deficiency. BCG vaccine is contraindicated in patients with SCID. Because most countries encourage BCG vaccination at birth, a high percentage of patients with SCID are vaccinated before their immune defect is detected.