Akademik Veri Yönetim Sistemi
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.48, sa.1, ss.384-395, 2024 (Scopus)
Objective: Three-dimensional (3D) printing, also known as additive manufacturing, has revolutionized various industrial fields such as engineering, architecture and space sciences. As a promising technology in the field of pharmacy in recent years, 3D printing appears as an advantageous approach to produce personalized solid dosage forms, implants and medical devices with high precision and accuracy. This technology has the potential to overcome some of the limitations of traditional pharmaceutical manufacturing processes and offers benefits such as improved dosage form design, increased patient compliance, and reduced manufacturing costs. Within the scope of this review, tablet production methods with 3D printing were examined. Result and Discussion: Among the different routes for administering dosage forms, the oral route is the most preferred route of administration regarding patient compliance. The production, processing and storage of tablets for oral administration is easier and more economical than other dosage forms. 3D printing enables the formulation and production of tablets with different geometric shapes and different active ingredient release profiles. Although this printing technology basically consists of the same printing stages, it is quite diversified within itself and is divided into seven different methods by the American Society for Testing and Materials. Among these various methods, the melt deposition modeling method, which is very successful in tablet production, has been the subject of many studies. However, tablets and caplets can be produced with all 3D printing methods. However, there is no established framework to demonstrate quality and safety for personalized medicines, and 3D technology may have risks such as counterfeit medicine, proliferation of illegal drugs and mislabeling. For 3D production, it is necessary to adopt good manufacturing practices (GMP), establish standard operating procedures, and conduct quality control (e.g. content uniformity, mass uniformity, dissolution testing in tablets) throughout the entire production line and subsequently on the finished product.