The inhibitory effects of thiazolyl-2,4-thiazolidinedione compounds on the rat kidney aldose reductase enzyme

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Ceylan Ünlüsoy M., Daş Evcimen N., Sarikaya M., Bozdač Dündar O., Ertan R.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.38, sa.3, ss.181-190, 2009 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1501/eczfak_0000000526
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.181-190
  • Anahtar Kelimeler: 2,4-Thiazolidinediones, Aldose reductase enzyme, Diabetes, Inhibition, Thiazole derivatives
  • Ankara Üniversitesi Adresli: Evet

Özet

Aldose reductase enzyme is the key factor in the reduction of glucose to sorbitol. Accumulation of sorbitol in diabetes causes complications such as diabetic cataract, retinopathy, neuropathy and nephropathy. Aldose reductase inhibitors have been found to prevent sorbitol accumulation in tissues. Numerous compounds have been prepared in order to improve the pharmacological profile of inhibition of aldose reductase enzyme. In this study, series of thiazolyl-2,4-thiazolidinediones (Ia-f, IIa-f and IIIa-f) were tested for their aldose reductase inhibitory activities. It was found that substituted-thiazolyl- thiazolidinedione derivatives showing very slight inhibitor activity.