Synthesis and antidiabetic activity of morpholinothiazolyl-2,4-thiazolidindione derivatives

Ezer M., Yildirim L. T., Bayro O., Verspohl E. J., Dundar O.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.27, sa.3, ss.419-427, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3109/14756366.2011.594047
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.419-427
  • Anahtar Kelimeler: Antidiabetic drugs, 2;4-thiazolidinediones, thiazolyl-2;4-thiazolidinediones, insulinotropic activity, glucose uptake, HYPOGLYCEMIC ACTIVITY, FLAVONE DERIVATIVES, SUBSTITUTED THIAZOLIDINEDIONES, ANTIMICROBIAL ACTIVITY, COMMUNICATION, THIAZOLIDINE-2,4-DIONE, 2,4-THIAZOLIDINEDIONE, ADIPOCYTES
  • Ankara Üniversitesi Adresli: Evet

Özet

We report the synthesis and the in vitro insulin releasing and glucose uptake activity of the morpholino thiazolyl-2,4-thiazolidinediones (1-15). Compounds 5, 11-15 (at lower concentration; 0.001 mg/ml) were able to increase insulin release in the presence of 5.6 mmol/l glucose. The compounds, except derivative 3 show an increase of glucose uptake. Various compounds are interesting potential antidiabetic leads showing pancreatic and extrapancreatic effects.