Post-natal oogenesis: a concept for controversy that intensified during the last decade

Esmaeilian Y., ATALAY A., ERDEMLİ E.

ZYGOTE, cilt.23, sa.3, ss.315-326, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 23 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1017/s0967199413000622
  • Dergi Adı: ZYGOTE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.315-326
  • Anahtar Kelimeler: Germline stem cell, Oocyte, Oogenesis, Ovarian stem cell, Ovary, GERMLINE STEM-CELLS, ADULT-MOUSE OVARY, BONE-MARROW, HEMATOPOIETIC STEM, NEO-OOGENESIS, FOLLICULAR RENEWAL, PROTEIN EXPRESSION, HOMING EFFICIENCY, NO EVIDENCE, RAT OVARY
  • Ankara Üniversitesi Adresli: Evet

Özet

For decades, scientists have considered that female mammals are born with a lifetime reserve of oocytes in the ovary, irrevocably fated to decline after birth. However, controversy in the matter of the possible presence of oocytes and granulosa cells that originate from stem cells in the adult mammalian ovaries has been expanded. The restricted supply of oocytes in adult female mammals has been disputed in recent years by supporters of neo-oogenesis, who claim that germline stem cells (GSCs) exist in the ovarian surface epithelium (OSE) or the bone marrow (BM). Differentiation of ovarian stem cells (OSCs) into oocytes, fibroblast-like cells, granulosa phenotype, neural and mesenchymal type cells and generation of germ cells from OSCs under the contribution of an OSC niche that consists of immune system-related cells and hormonal signalling has been claimed. Although these arguments have met with intense suspicion, their confirmation would necessitate the revision of the current classic knowledge of female reproductive biology.