Cisplatin causes oxidation in rat liver tissues: Possible protective effects of antioxidant food supplementation

Avci A., Cetin R., Erguder I. B., DEVRİM E., Kilicoglu B., Candir O., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.38, no.2, pp.117-120, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 2
  • Publication Date: 2008
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.117-120
  • Keywords: cisplatin, hepatotoxicity, antioxidant foods, protection, SUPEROXIDE-DISMUTASE ENZYMES, TOXICITY, LYCOPENE, OXIDASE, WINE, MICE
  • Ankara University Affiliated: Yes

Abstract

Aims: In this study, we aimed to investigate the possible molecular mechanism of cisplatin hepatotoxicity and to establish whether some natural antioxidant foods, namely dried black grape and tomato, may provide protection against cisplatin hepatotoxicity.