Impact of harvest product volume in erythrocyte depletion of allogeneic or autologous bone marrow using COBE spectra
TRANSFUSION AND APHERESIS SCIENCE, cilt.36, sa.3, ss.269-273, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 36 Sayı: 3
- Basım Tarihi: 2007
- Doi Numarası: 10.1016/j.transci.2007.03.006
- Dergi Adı: TRANSFUSION AND APHERESIS SCIENCE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.269-273
- Anahtar Kelimeler: erythrocyte depletion, cell separator, bone marrow, harvest volume, STEM-CELL TRANSPLANTATION, MONONUCLEAR-CELLS, SEPARATOR, BLOOD, IMPLANTATION, GRAFTS
- Ankara Üniversitesi Adresli: Evet
Özet
Depletion of bone marrow (BM) from erythrocytes is used to prevent early hemolysis in major ABO incompatible allogeneic hematopoictic cell transplantation (Allo-HCT). This method was also strongly recommended before storing of autologous and even allo-BM for volume reduction in order to prevent early hemolysis and DMSO toxicity after infusion. In our center, erythrocyte depletion of BM harvests has been performed on a continuous flow cell separator, which used a closed system with a high mononuclear cell (MNC) yield and low rate of erythrocyte contamination. According to the protocol of a cellular therapy approach in a cardiovascular collaborative study we have to adopt the process to lower volumes. We aimed to compare our results with standard volume (SV) (historical control) to low volume ED procedures.