Synthesis of new indole-2-carboxamide and 3-acetamide derivatives and evaluation their antioxidant properties

Olgen S., BAKAR ATEŞ F., Aydin S., Nebioglu D., Nebioglu S.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.28, sa.1, ss.58-64, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/14756366.2011.631183
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.58-64
  • Anahtar Kelimeler: Indole-2-carboxamide and 3-acetamide, hemeoxygenase, DPPH, antioxidant, HEME OXYGENASE, N-H, INDOLE-DERIVATIVES, SUBSTITUTED INDOLE, INHIBITORS, SERIES, MONOXIDE, PROTEIN, STRESS, SYSTEM
  • Ankara Üniversitesi Adresli: Evet

Özet

In recent years, antioxidant compounds play an important role as a health-protecting factor. Antioxidants protect cells against the damaging effects of reactive oxygen species (ROS). An imbalance between antioxidants and ROS results in oxidative stress, which leads to cellular damage and it is linked to many vital diseases. It was shown that heme oxygenase (HO) provides efficient cytoprotection against oxidative stress. In this study, a series of indole-2-carboxamide and 3-acetamide derivatives was tested for in vitro effects on HO activity and 2,2-diphenyl-1-picrylhydrazyl (DPPH) inhibition. Among the synthesized compounds, N-[3-(dimethylamino)propyl]-1H-indole-2-carboxamide 3 was found as the most activator of HO and N-(2-(dimethylamino)ethyl)-2-(1H-indol-3-yl)acetamide 8 was found the most potent inhibitor for DPPH at 10(-4) M concentration.