Association of Glial Cell-Line Derived Neurotrophic Factor and Nerve Growth Factor with Duration of Untreated Psychosis and Clinical Symptoms in Drug-Naive Schizophrenia

Tikir B., Asan O., Uzdogan A., Sahiner Ş., Goka E.

PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, vol.31, no.3, pp.252-260, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.5152/pcp.2021.21715
  • Journal Name: PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.252-260
  • Keywords: Glial cell-line derived neurotropic factor (GDNF), Nerve growth factor (NGF), Positive and Negative Syndrome Scale (PANSS), Schizophrenia, FACTOR GDNF GENE, SERUM-LEVELS, NEUROBIOLOGICAL DEVELOPMENT, BDNF LEVELS, NICOTINE, POLYMORPHISM, MECHANISMS, HYPOTHESIS, DISORDER, RECEPTOR
  • Ankara University Affiliated: No

Abstract

Background: The neurodevelopmental hypothesis is one of the most-emphasized hypotheses in the etiology of schizophrenia. Nerve growth factor (NGF) and glial cell-line derived neurotropic factor (GDNF) are neurotrophic factors that provide growth, differentiation, and survival in nerve cells in the development process. In this study, we aimed to compare the GDNF and NGF levels of schizophrenia patients with healthy controls and to analyze the relationship between the Positive and Negative Syndrome Scale (PANSS) scores, serum GDNF and NGF levels and the duration of untreated psychosis (DUP) of the patients.