Effect of levothyroxine replacement therapy on paraoxonase-1 and carotid intima-media thickness in subclinical hypothyroidism

Kebapcilar L., ÇÖMLEKÇİ A., TUNCEL E. P., Solak A., SEÇİL M., Gencel O., ...Daha Fazla

MEDICAL SCIENCE MONITOR, cilt.16, sa.1, 2010 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 1
  • Basım Tarihi: 2010
  • Dergi Adı: MEDICAL SCIENCE MONITOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: paraoxonase-1, carotid intima-media thickness, subclinical hypothyroidism, C-REACTIVE PROTEIN, HIGH-DENSITY-LIPOPROTEIN, CORONARY-HEART-DISEASE, RISK-FACTORS, CARDIOVASCULAR-DISEASE, MYOCARDIAL-INFARCTION, FOLLOW-UP, INDEPENDENT PREDICTOR, LIPID PROFILE, ATHEROSCLEROSIS
  • Ankara Üniversitesi Adresli: Hayır

Özet

Background: Paraoxonase-1 (PON-1) may play an important role in atherosclerosis. Atherosclerosis is an inflammatory disease and C-reactive protein is a marker for inflammation. The aim of this study was to determine serum PON-1 activity and high-sensitivity C-reactive protein (hs-CRP) levels and assess carotid intima-media thickness, a marker of early atherosclerotic changes, in patients with subclinical hypothyroidism.