High mobility group box-1 levels may be associated with disease activity of Behcet's disease

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Donmez Guler D., Kelesoglu Dincer A. B., KARAHAN Z. C., Guler H. S., Yayla M. E., Sezer S., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.51, sa.5, ss.2690-2697, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3906/sag-2101-116
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.2690-2697
  • Anahtar Kelimeler: High mobility group box-1, autoimmune diseases, Behcet's disease, inflammation, SERUM-LEVELS, HMGB1, CHROMOSOMAL-PROTEIN-1, PATHOGENESIS, INFLAMMATION, ACTIVATION, EXPRESSION, AUTOIMMUNE, RECEPTOR, PATHWAY
  • Ankara Üniversitesi Adresli: Evet

Özet

Background/aim: High mobility group box-1 (HMGB-1) is a nuclear protein acting as a proinflammatory molecule. The serum HMGB- 1 levels were found elevated in chronic inflammatory diseases. In this cross-sectional study, serum HMGB- 1 levels in Behcet's disease (BD) patients and healthy controls (HC) were studied. Also, its association with disease activity scores and clinical findings were evaluated.