Maturity onset diabetes of youth (MODY) in Turkish children: sequence analysis of 11 causative genes by next generation sequencing

Agladioglu, Sebahat; AYCAN, ZEHRA; Cetinkaya, Semra; Bas, Veysel; Onder, Asan; Kendirci, Havva; Dogan, Haldun; Ceylaner, Serdar

doi:10.1515/jpem-2015-0039

Maturity onset diabetes of youth (MODY) in Turkish children: sequence analysis of 11 causative genes by next generation sequencing

Agladioglu S. Y., AYCAN Z., Cetinkaya S., Bas V. N., Onder A., Kendirci H. N. P., ...Daha Fazla

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, cilt.29, sa.4, ss.487-496, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 29 Sayı: 4
Basım Tarihi: 2016
Doi Numarası: 10.1515/jpem-2015-0039
Dergi Adı: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.487-496
Anahtar Kelimeler: children, maturity onset diabetes of youth (MODY), next generation sequencing, HEPATOCYTE NUCLEAR FACTOR-1-ALPHA, YOUNG MODY, MUTATIONS, TYPE-2, DIAGNOSIS, DIFFERENTIATION, HETEROGENEITY, FAMILIES, MELLITUS, ACID
Ankara Üniversitesi Adresli: Hayır

Özet

Background: Maturity-onset diabetes of the youth (MODY), is a genetically and clinically heterogeneous group of diseasesand is often misdiagnosed as type 1 or type 2 diabetes. The aim of this study is to investigate both novel and proven mutations of 11 MODY genes in Turkish children by using targeted next generation sequencing.