The Role of Psychosocial Factors in Etiology of Schizophrenia: From Antipsychiatry to Gene-Environment Interactions

BASKAK B., Atbasoglu C., SAKA M. C.

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, cilt.46, ss.1-9, 2009 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46
  • Basım Tarihi: 2009
  • Dergi Adı: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1-9
  • Anahtar Kelimeler: Schizophrenia-etiology, urbanization, social capital, URBAN, NEIGHBORHOOD, ASSOCIATION, ILLNESS, AREAS, RISK
  • Ankara Üniversitesi Adresli: Evet

Özet

Psychosocial factors in the etiology of schizophrenia had been a subject of research for more than 70 years, but in relatively limited number of studies. This relationship had been interpreted and/or neglected depending on the socio-politic preferences of the decade and the dominant psychiatric notion of the period. Recently, gene-environment interaction models allowed us to approach the issue more objectively. Urbanization has an increasing rate worldwide and is an important risk indicator that might be affecting, with a modest effect size, one third of schizophrenia incidences. Therefore, it is crucial to determine the risk factor(s) related to urbanization in order to better understand the etiology of schizophrenia. This review begins with a chronologic summary of discussions on the psychosocial factors in schizophrenia and proceeds by introducing the model of gene-environment interactions. The association between urbanization, social capital and schizophrenia will later be reviewed in terms of gene-environment interactions and finally, we are going to discuss the causal relationship between urbanization and schizophrenia. (Archives of Neuropsychiatry 2009; 46 Supplement: 1-9)