Synthesis of novel 2-[4-(4-substitutedbenzamido/phenylacetamido)phenyl]benzothiazoles as antimicrobial agents

BOLELLİ K., Yalcin I., ERTAN BOLELLİ T., Ozgen S., Kaynak-Onurdag F., YILDIZ İ., ...Daha Fazla

MEDICINAL CHEMISTRY RESEARCH, cilt.21, sa.11, ss.3818-3825, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 11
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s00044-011-9918-4
  • Dergi Adı: MEDICINAL CHEMISTRY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3818-3825
  • Anahtar Kelimeler: Benzothiazole, Antibacterial activity, Antifungal activity, Multi-drug resistance, TOPOISOMERASE-II INHIBITORS, ANTITUMOR BENZOTHIAZOLES, BENZIMIDAZOLES, BENZOXAZOLES, DERIVATIVES, 3D-QSAR, ACID
  • Ankara Üniversitesi Adresli: Evet

Özet

A new series of 2-[4-(4-substitutedbenzamido/phenylacetamido)phenyl] benzothiazole derivatives (6a-k) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli with their drug-resistant isolates and a yeast Candida albicans. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at minimum inhibitory concentration (MIC) values between 100 and 6.25 mu g/ml. Compounds 6d and 6k exhibited significant antibacterial activity showing 6.25 mu g/ml MIC values against drug-resistant S. aureus and P. aeruginosa isolates, respectively.