Antioxidative metabolism in Down syndrome

TEKŞEN A. F., Sayli B., Aydin A., Sayal A., Isimer A.

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.63, sa.2, ss.123-127, 1998 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 2
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1007/bf02778871
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.123-127
  • Anahtar Kelimeler: Down syndrome, superoxide dismutase, glutathione peroxidase, zinc, copper, selenium, GLUTATHIONE-PEROXIDASE ACTIVITY, DOWNS-SYNDROME, SUPEROXIDE-DISMUTASE, HUMAN TRISOMY-21, ERYTHROCYTES, SELENIUM, SUPPLEMENTATION, DEFENSE, PLASMA, CELLS
  • Ankara Üniversitesi Adresli: Evet

Özet

Down syndrome is the most common cause of mental retardation, affecting 1 in 700-800 liveborn infants. Although numerous biochemical abnormalities accompanying the syndrome have not yet been completely clarified, the antioxidant defense system enzymes have shown to be altered due to increased gene dosage on chromosome 21 and overproduction of superoxide dismutase (SOD-1 or Cu/Zn SOD). The purpose of this study was to investigate the activities of SOD-1 and glutathione peroxidase (GSH-Px) enzymes and the levels of their cofactors zinc (Zn), copper (Cu) and selenium (Se) in plasma of 20 Down syndrome patients.