Effects of adrenomeduline and ramp2 on the lung of mice exposed to total body radiation
INTERNATIONAL JOURNAL OF RADIATION RESEARCH, cilt.18, sa.3, ss.571-578, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 3
- Basım Tarihi: 2020
- Doi Numarası: 10.18869/acadpub.ijrr.18.3.571
- Dergi Adı: INTERNATIONAL JOURNAL OF RADIATION RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.571-578
- Anahtar Kelimeler: AM, RAMP2, radiation, lung, carcinogens, ENDOTHELIAL ADRENOMEDULLIN-RAMP2 SYSTEM, HYPOTENSIVE PEPTIDE, VASCULAR INTEGRITY, CANCER CELLS, KAPPA-B, GROWTH, ANGIOGENESIS, EXPRESSION, VEGF
- Ankara Üniversitesi Adresli: Evet
Özet
Background: Adrenomedullin (AM) and its receptor, receptor activity-modifying protein (RAMP) 2 have pleiotropic regulatory functions in normal tissue and cancer tissue. AM is produced and secreted both numerous stromal cells and tumor cells. This study aims to investigate a possible role of AM and RAMP2 in the radiation exposure in the normal lung tissue. Materials and Methods: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice were subjected to a 500 cGy single-dose radiation exposure in the total body radiation device and lung tissues were collected. 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. Results: The general histology and the immunohistochemistry of the tissue samples prepared with anti-AM, anti-RAMP2, and monoclonal antibodies were investigated, yielding a statistically significant increase for AM on day 3 and for RAMP2 on day 1 after radiation exposure. Conclusion: The observed increase of AM and RAMP2 concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy.