SPECTROPHOTOMETRIC DETERMINATION OF ACTIVE COMPOUNDS IN AN ANTIHYPERTENSIVE FORMULATION BY HAAR-CWT METHOD BİR ANTİHİPERTANSİF FORMÜLASYONDAKİ AKTİF BİLEŞİKLERİN HAAR-CWT YÖNTEMİYLE SPEKTROFOTOMETRİK TAYİNİ

ÜSTÜNDAĞ Ö., DİNÇ E.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.45, sa.3, ss.535-544, 2021 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.33483/jfpau.986786
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.535-544
  • Anahtar Kelimeler: Hydrochlorothiazide, Irbesartan, Quantitative determination, Spectrophotometry, Wavelet transform
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: In present work, we developed a new wavelet method (HAAR-CWT) to determine the amounts of irbesartan (IR) and hydrochlorotizide (HC) active compounds simultaneously in an antihypertensive formulation, and after validating this method, we successfully applied it to the assay of tablets containing the above-mentioned compounds. Material and Method: The absorption spectra of mixtures and tablet solutions in the spectral range 200-305 nm were measured by a Shimadzu UV-1601 dual-beam UV-VIS spectrophotometer. Result and Discussion: Due to the strong overlapping spectra of the mentioned components, the HAAR-CWT method has been proposed and successfully applied to the ratio spectra of IR-HC mixtures and tablets.