Nanodesigning of multifunctional quantum dots and nanoparticles for the treatment of fibrosarcoma

Demirbolat G. M., ALTINTAŞ L., Yilmaz S., Arsoy T., SÖZMEN M., DEĞİM İ. T.

JOURNAL OF MICROENCAPSULATION, cilt.39, sa.3, ss.210-225, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/02652048.2021.1990423
  • Dergi Adı: JOURNAL OF MICROENCAPSULATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.210-225
  • Anahtar Kelimeler: Imatinib mesylate, dexketoprofen trometamol, synergetic effects, ZnO quantum dots, chitosan nanoparticles, fibrosarcoma, cancer treatment, DRUG-DELIVERY SYSTEMS, IMATINIB MESYLATE, CHITOSAN, RELEASE, CELL, NANOTECHNOLOGY, TRANSPORT, CANCER, DOXORUBICIN, GENERATION
  • Ankara Üniversitesi Adresli: Evet

Özet

An effective, dual drug(DD) loaded nanocarrier system (nano particle(NP), quantum dots(QDs)) having two active substances was aimed to develop for the treatment of fibrosarcoma. Zinc oxide(ZnO) QDs were produced using zinc acetate dehydrate as a precursor, were incorporated with chitosan(Ch), and finally decorated with PEG-linked folic acid and were found to be effective after imatinib mesylate(IM) and dexketoprofen trometamol(DT) were loaded. Characterisations, in vitro drug releases, cell toxicities, penetrations through cell lines and in-vivo animal tests of the prepared nanosystems were performed. The size of hybrid nanoparticles were 168.6 +/- 48.8 nm, surface charge was -35.8 +/- 0.26 mV. The encapsulation efficiency was 75% for IM and 99% for DT. DD-functionalised QDChNPs and lyophilised functionalised QDChNPs in capsules slowed down tumour growth by up to 76.5 and 88.7%. Our results demonstrate that developed hybrid nanoparticles are highly effective. This hybrid system gathers many of the advantages of nanotechnology into one form.