A study of the histamine H2-receptors in heart muscle and coronary vessels

Ercan Z., Bökesoy T., Türker R.

European Journal of Pharmacology, vol.27, no.2, pp.259-262, 1974 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 1974
  • Doi Number: 10.1016/0014-2999(74)90156-3
  • Journal Name: European Journal of Pharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.259-262
  • Keywords: Coronary vessels, H2-receptors, Heart muscle, Histamine, Metiamide
  • Ankara University Affiliated: Yes

Abstract

Effects of histamine on cardiac force, heart rate and coronary perfusion were studied in the isolated perfused guinea-pig heart. The amine induced an increase in contractile force, heart rate and a decrease in coronary perfusion pressure. Metiamide, a potent antagonist of histamine H2-receptors, competitively inhibited these effects. It is concluded that these effects of histamine in the isolated perfused guinea-pig heart are probably mediated by histamine H2-receptors. © 1974.