Akademik Veri Yönetim Sistemi
STP PHARMA SCIENCES, cilt.6, sa.4, ss.312-315, 1996 (SCI-Expanded, Scopus)
In this paper two new spectrophotometric methods were used for the simultaneous determination of metronidazole aid miconazole nitrate in their binary mixture. In the first method, derivative spectrophotometry, dA/d lambda values were measured at 328.6 and 230.8 nm for metronidazole and miconazole nitrate, respectively, in the first derivative spectra of their combination. The relative standard deviation of the method was found to be 0.21% for metronidazole and 0.50% for miconazole nitrate. In the other method, the absorbency ratio method, the quantification of metronidazole and miconazole nitrate was performed by using rite absorbencies read at 310.4, 280.6 and 272.0 nm in the zero-order spectra of their mixture. The relative standard deviation of the method was found to be 0.67 and 0.85% for metronidazole and miconazole nitrate, respectively. These two methods have been successfully applied to an ovule containing only these drugs.