The effect of renal replacement therapy on health-related quality of life in end-stage renal disease: a meta-analysis

Fidan C., AĞIRBAŞ İ.

Clinical and Experimental Nephrology, cilt.27, sa.10, ss.829-846, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 10
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s10157-023-02377-3
  • Dergi Adı: Clinical and Experimental Nephrology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.829-846
  • Anahtar Kelimeler: Dialysis treatment methods, End-stage renal disease, Health-related quality of life, Kidney transplantation, Meta analysis, ASSISTED PERITONEAL-DIALYSIS, NOCTURNAL HOME HEMODIALYSIS, KIDNEY-TRANSPLANTATION, PUBLICATION BIAS, OLDER PATIENTS, SELF-EFFICACY, MODALITIES, FAILURE, BRAZIL, FILL
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: End-stage renal disease (ESRD) patients judge health-related quality of life (HRQoL) as an essential outcome. In meta-analysis studies, there is ongoing debate regarding the impact of renal replacement therapy (RRT) methods on HRQoL in ESRD patients. Hence, the main objective of this study was to examine the influence of RRT method utilization on HRQoL in individuals with ESRD. Additionally, the secondary objective was to explore the impact of RRT method use on HRQoL, considering various moderator variables. Methods: RRT methods called hemodialysis (HD), peritoneal dialysis (PD), home dialysis (HoD), and kidney transplantation (KT) are used to treat ESRD. HD was defined as in-center HD (ICHD) and home HD (HHD). HoD was defined as HHD and PD. The estimated Hedges’ g were conducted by random effect meta-analysis. Results: A total of 111 publications, including 50.151 patients, were included. KT was better at improving patients’ HRQoL than other methods. PD was better at improving patients’ HRQoL than HD. HoD was better at improving patients’ HRQoL than ICHD. Sensitivity analyses yielded similar results. Publication bias was not tested. The subgroup and meta-regression analyses showed that the moderating variables had a statistically significant effect on the HRQoL of patients with ESRD. Conclusion: For the treatment of ESRD, either KT, PD, or HoD can be used in terms of HRQoL. We need to improve the factors affecting the HRQoL of ESRD patients undergoing HD and ICHD. Healthcare professionals should consider the factors that influence HRQoL and choose an RTT method for each ESRD patient.