Use of aspirin in patients taking angiotensin converting enzyme inhibitors

Altin T., Kilickap M.

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.7, ss.14-19, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7
  • Basım Tarihi: 2007
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.14-19
  • Anahtar Kelimeler: angiotensin converting enzyme inhibitors, aspirin, bradykinin, interaction, CONGESTIVE-HEART-FAILURE, LEFT-VENTRICULAR DYSFUNCTION, ACUTE MYOCARDIAL-INFARCTION, CORONARY-ARTERY-DISEASE, LOW-DOSE ASPIRIN, ACE-INHIBITORS, ENALAPRIL, SURVIVAL, THERAPY, MORTALITY
  • Ankara Üniversitesi Adresli: Evet

Özet

Aspirin and angiotensin converting enzyme (ACE) inhibitors both have beneficial effects on prognosis in patients with cardiovascular disease. For this reason, they are usually prescribed together. Some of the beneficial effects of ACE inhibitors are thought to be due to reduced degradation of bradykinin. Bradykinin enhances nitric oxide and vasodilatory prostaglandins. Theoretically, aspirin, which inhibits cyclooxygenase enzyme, may reduce bradykinin mediated prostaglandin synthesis and blunt the beneficial effects of ACE inhibitors, when used together. Although some hemodynamic studies support this hypothesis, clinical studies have conflicting results. In this article, we reviewed the possible interaction between aspirin and ACE inhibitors in light of literature findings.