Late recurrence of sigmoid carcinoma mimicking primary vulvar cancer: case report and review of the literature

Pabuccu E., Tolunay H. E., Kocbulut E., TAŞKIN S., Ortac F., Sertcelik A., ...Daha Fazla

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, cilt.5, sa.6, ss.609-613, 2012 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 5 Sayı: 6
  • Basım Tarihi: 2012
  • Dergi Adı: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.609-613
  • Anahtar Kelimeler: Colon, immunohistochemistry, metastasis, sigmoid, vulva, COLORECTAL-CANCER, UNKNOWN PRIMARY, METASTASES, ADENOCARCINOMA, CYTOKERATIN-20, SECONDARY, TUMORS
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: To demonstrate a unique case report about late and isolated vulvar metastasis of sigmoid adeno-carcinoma with review of the literature. Material-method: 57 year old postmenopausal patient with prior sigmoid colon cancer history was admitted with isolated vulvar mass. Immunohistochemistry (IHC) and KRAS gen mutation analysis following surgery were performed to discriminate the metastasis from a vulvar primary malignancy. Further imaging techniques were also performed to exclude additional tumours. Results: Immunohistochemistry (IHC) and KRAS gene mutation analysis revealed isolated metastasis of the colonic adeno-carcinoma in the vulva. Conclusion: Isolated and late occurring vulvar metastasis of colonic origin is very unusual. Careful evaluation and IHC is useful for such cases.