Submission to Stem Cells Reviews and Reports

Escribá R., Beksac M., Bennaceur-Griscelli A., Glover J. C., Koskela S., Latsoudis H., ...Daha Fazla

Stem Cell Reviews and Reports, cilt.20, sa.8, ss.2155-2164, 2024 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 8
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1007/s12015-024-10783-7
  • Dergi Adı: Stem Cell Reviews and Reports
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, MEDLINE
  • Sayfa Sayıları: ss.2155-2164
  • Anahtar Kelimeler: Haplobanks, HLA-homozygous, HLA-match, Induced pluripotent stem cells, Regenerative medicine
  • Ankara Üniversitesi Adresli: Hayır

Özet

The use of allogeneic induced pluripotent stem cell (iPSC)-derived cell therapies for regenerative medicine offers an affordable and realistic alternative to producing individual iPSC lines for each patient in need. Human Leukocyte Antigens (HLA)-homozygous iPSCs matched in hemi-similarity could provide cell therapies with reduced immune rejection covering a wide range of the population with a few iPSC lines. Several banks of HLA-homozygous iPSCs (haplobanks) have been established worldwide or are underway, to provide clinical grade starting material for cell therapies covering the most frequent HLA haplotypes for certain populations. Harmonizing quality standards among haplobanks and creating a global registry could minimize the collective effort and provide a much wider access to HLA-compatible cell therapies for patients with less frequent haplotypes. In this review we present all the current haplobank initiatives and their potential benefits for the global population. Graphical Abstract: (Figure presented.)