Induction of sister chromatid exchanges and cell division delays by clomiphene citrate in human lymphocytes

Yilmaz S., ÜNAL F., Yuzbasioglu D., Gonenc İ. M.

HUMAN & EXPERIMENTAL TOXICOLOGY, vol.34, no.3, pp.284-288, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.1177/0960327114537846
  • Journal Name: HUMAN & EXPERIMENTAL TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.284-288
  • Keywords: Clomiphene citrate, genotoxicity, sister chromatid exchanges, cell cycle delay, CANCER INCIDENCE, OVARIAN-CANCER, OVULATION INDUCTION, FERTILITY DRUGS, UTERINE-CANCER, BREAST-CANCER, IN-VIVO, RISK, INFERTILITY, COHORT
  • Ankara University Affiliated: Yes

Abstract

Objective: Clomiphene citrate (CC) is a selective estrogen receptor modulator and is used for the treatment of in vitro fertilization, intracytoplasmic sperm injection, intrauterine insemination, and so on. In this study, sister chromatid exchanges (SCEs) and cell cycle delays were analyzed to investigate genotoxicity and cytotoxicity of CC in peripheral blood lymphocytes of healthy women.