Akademik Veri Yönetim Sistemi
Microchemical Journal, cilt.226, 2026 (SCI-Expanded, Scopus)
A sensitive and green electroanalytical approach was established for the determination of binimetinib (BINI) using a rationally engineered two-dimensional/two-dimensional (2D/2D) graphitic carbon nitride/hexagonal boron nitride (g-C₃N₄/h-BN) heterostructure – modified glassy carbon electrode (GCE). The intimate interfacial contact between the layered nanosheets promotes efficient charge delocalization and accelerates interfacial electron-transfer kinetics, as confirmed by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Under optimized differential pulse voltammetry (DPV) conditions, the sensor exhibited a wide linear response over the concentration range of 1.0–26.34 μM with an ultra-low detection limit (LOD) of 3.78 nM (3σ/S). The oxidation process was found to follow an irreversible 2e−/2H+ mechanism governed predominantly by diffusion, supported by Laviron-based kinetic analysis. The modified electrode demonstrated excellent repeatability (RSD 1.03%), reproducibility (RSD 0.95%), long-term stability (20 days), and strong anti-interference capability. The method was successfully applied to pharmaceutical formulations and biological matrices with satisfactory recoveries (96.8–103.9%). Furthermore, greenness assessment using the Greenness evaluation metric for analytical methods (GEMAM) metric yielded a score of 5.387, confirming the environmental compatibility of the analytical platform. The synergistic integration of structural conductivity enhancement and optimized interfacial charge transport renders the g-C₃N₄/h-BN heterostructure a promising sensing interface for kinase inhibitor analysis.