Comparative application of PLS and PCR methods to simultaneous quantitative estimation and simultaneous dissolution test of zidovudine - Lamivudine tablets

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ÜSTÜNDAĞ Ö., DİNÇ E., Ozdemir N., Tilkan M. G.

Acta Chimica Slovenica, cilt.62, sa.2, ss.437-444, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.17344/acsi.2014.1071
  • Dergi Adı: Acta Chimica Slovenica
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.437-444
  • Anahtar Kelimeler: PLS, PCR, chemometrics, Anti-HIV, dissolution, FIXED-DOSE COMBINATIONS, CONTINUOUS WAVELET, ANTIRETROVIRAL DRUGS, CHEMOMETRIC METHODS, HUMAN SERUM, RP-HPLC, NEVIRAPINE, STAVUDINE, MIXTURE, TRANSFORMS
  • Ankara Üniversitesi Adresli: Evet

Özet

In the development strategies of new drug products and generic drug products, the simultaneous in-vitro dissolution behavior of oral dosage formulations is the most important indication for the quantitative estimation of efficiency and biopharmaceutical characteristics of drug substances. This is to force the related field's scientists to improve very powerful analytical methods to get more reliable, precise and accurate results for the quantitative analysis and dissolution testing of drug formulations. In this context, two new application of partial least squares (PLS) and principal component regression (PCR) were applied for the simultaneous quantitative estimation and dissolution testing of zidovudine (ZID) and lamivudine (LAM) in a tablet dosage form. The results obtained in this study strongly encourage us to use them for the quality control, the routine analysis and the dissolution test of the marketing tablets containing ZID and LAM drugs.