Hypophosphatasia associated with pseudotumor cerebri and respiratory insufficiency

TEBER S., Sezer T., Kafali M., KENDİRLİ T., ŞIKLAR Z., BERBEROĞLU M., ...Daha Fazla

INDIAN JOURNAL OF PEDIATRICS, cilt.75, sa.2, ss.186-188, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 75 Sayı: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s12098-008-0029-2
  • Dergi Adı: INDIAN JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.186-188
  • Anahtar Kelimeler: infantile hypophosphatasia, pseudotumor cerebri, respiratory insufficiency, RICKETS
  • Ankara Üniversitesi Adresli: Evet

Özet

We report a 3-month-old male with infantile hypophosphatasia who later developed Pseudotumor cerebri. At the age of 3 months, he was referred to our hospital because of pneumonia and respiratory insufficiency. He had short extremities, and radiographs of the bones were consistent with lack of metaphyseal mineralization and bowed lower extremities. Vomiting and bulging fontanelle developed 3 months after admission, and CSF openning pressure was notably high at 430 mm/H(2)O. Hypophosphatasia is a very rare cause of pseudotumor cerebri. This report is the first case where PTC is associated with hypophosphatasia and responded well to corticosteroid therapy.