Continuous intracranial administration of suberoylanilide hydroxamic acid (SAHA) inhibits tumor growth in an orthotopic glioma model

Ugur H. C., Ramakrishna N., Bello L., Menon L. G., Kim S., Black P. M., ...Daha Fazla

JOURNAL OF NEURO-ONCOLOGY, cilt.83, sa.3, ss.267-275, 2007 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 83 Sayı: 3
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s11060-007-9337-z
  • Dergi Adı: JOURNAL OF NEURO-ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.267-275
  • Anahtar Kelimeler: histone deacetylase inhibitor, glioma, local delivery, SAHA, HISTONE DEACETYLASE INHIBITOR, CANCER-CELL-GROWTH, IN-VIVO, MALIGNANT GLIOMAS, ANTINEOPLASTIC ACTIVITY, CARCINOMA CELLS, HDAC INHIBITOR, BRAIN-TUMORS, DNA-REPAIR, PHASE-I
  • Ankara Üniversitesi Adresli: Hayır

Özet

Object Current treatments for malignant gliomas produce only a modest increase in survival time. New therapeutic approaches are desperately needed. Suberoylanilide hydroxamic acid (SAHA) is an effective inhibitor of the growth of many solid and hematological malignancies. Nevertheless, very few studies have investigated the effects of SAHA on glial tumors. The present study was designed to investigate the therapeutic effects of the intracranial local delivery of SAHA in an orthotopic glioma model.