Friend leukemia virus integration-1 (FLI-1) expression in gastrointestinal stromal tumors

KAYGUSUZ G., KUZU I.

TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.20, sa.2, ss.83-86, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 2
  • Basım Tarihi: 2009
  • Dergi Adı: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.83-86
  • Anahtar Kelimeler: Friend leukemia virus integration-1, Ewing's sarcoma/primitive neuroectodermal tumor, gastrointestinal stromal tumor, EWINGS-SARCOMA, IMMUNOHISTOCHEMICAL DETECTION, EWS/ETS FUSIONS, CELL TUMORS, ROUND-CELL, KIT, CONSISTENCY, PHENOTYPE, EWS/FLI-1, ANTIBODY
  • Ankara Üniversitesi Adresli: Evet

Özet

Background/aims: Friend leukemia virus integration-1 expression has been shown in a variety of tumors, including vascular tumors, desmoplastic small round cell tumor, Merkel cell carcinoma, and lymphoblastic lymphoma in addition to Ewing's sarcoma I primitive neuroectodermal tumor. The aim of the current study was to examine Friend leukemia virus integration-1 protein expression in a series of gastrointestinal stromal tumors and also to assess if Friend leukemia virus integration-1 has any role in the disease process. It is the first study analyzing Friend leukemia virus integration-1 expression in gastrointestinal stromal tumors in the English literature. Methods: A tissue mieroarray block containing 52 cases of gastrointestinal stromal tumors was done. Immunohistochemical analysis was performed for Friend leukemia virus integration-1 polyclonal antibody. Results: Immunohistochemically, Friend leukemia virus integration-1 was negative in all cases. Conclusions: Friend leukemia virus integration-1 can be expressed in a variety of tumors, and is helpful in making the diagnosis of Ewing's sarcoma/primitive neuroectodermal tumor. We think that this protein is not expressed in gastrointestinal stromal tumors and it is not a part of the pathogenesis of this disease.