Synthesis and antimicrobial activity of some novel 2,6,7-trisubstituted-2H-3,4-dihydro-1,4-benzoxazin-3-one derivatives
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, cilt.42, sa.4, ss.905-909, 2003 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 4
- Basım Tarihi: 2003
- Dergi Adı: INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
- Sayfa Sayıları: ss.905-909
- Ankara Üniversitesi Adresli: Evet
Özet
The synthesis of a new series of 2H-3,4-dihydro-1,4-benzoxazin-3-one derivatives 1-8 is accomplished in order to determine their antimicrobial activities and study their structure-activity relationships (SAR). The synthesized compounds have been tested in vitro against two Gram-positive, three Gram-negative bacteria and the fungus Candida albicans. The in vitro activity results show that the synthesized compounds exibit MIC values between 50-12.5 mug/mL for the antimicrobial activity against the tested microorganisms. The antibacterial and antifungal activities of the compounds 1-8 are also compared to several standard drugs.