Akademik Veri Yönetim Sistemi
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, cilt.42, sa.4, ss.905-909, 2003 (SCI-Expanded)
The synthesis of a new series of 2H-3,4-dihydro-1,4-benzoxazin-3-one derivatives 1-8 is accomplished in order to determine their antimicrobial activities and study their structure-activity relationships (SAR). The synthesized compounds have been tested in vitro against two Gram-positive, three Gram-negative bacteria and the fungus Candida albicans. The in vitro activity results show that the synthesized compounds exibit MIC values between 50-12.5 mug/mL for the antimicrobial activity against the tested microorganisms. The antibacterial and antifungal activities of the compounds 1-8 are also compared to several standard drugs.