The relationship of PON1 QR 192 and LM 55 polymorphisms with serum paraoxonase activities of Turkish diabetic patients

Altuner D., ATEŞ İ., SÜZEN H. S., Koc G. V., Aral Y., Karakaya A.

TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.27, sa.10, ss.873-878, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 10
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1177/0748233711399317
  • Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.873-878
  • Anahtar Kelimeler: Serum PON1 activities, PON1 QR192 polymorphism, PON1 LM55 polymorphism, lipid peroxidation, diabetes, HIGH-DENSITY-LIPOPROTEIN, GENE POLYMORPHISMS, MOLECULAR-BASIS, ARYLESTERASE, POPULATION, MELLITUS, DISEASES, LIPIDS
  • Ankara Üniversitesi Adresli: Evet

Özet

Paraoxonase (PON1) is a serum esterase responsible for the protection against xenobiotics toxicity such as paraoxon. Alterations in PON1 concentrations have been reported in a variety of diseases including diabetes mellitus (DM). It has been shown that the serum PON1 concentration and activity are decreased in patients with both type 1 and type 2 DM. This study aimed to investigate the lipid profiles and the relationship between PON1 activity and PON1, QR192 and LM55 polymorphisms in Turkish type 2 diabetic patients and non-diabetic control subjects. According to our results, RR variant had significantly higher PON activity than QQ and QR variants (p < 0.01) and LL variant had significantly higher PON activity than MM variant in both control and patient groups (p < 0.05). In conclusion, we found that PON1 192RR and 55LL genotypes are associated with higher PON activity than QQ and MM genotypes. This may be more protective to lipid peroxidation.