The relationship of PON1 QR 192 and LM 55 polymorphisms with serum paraoxonase activities of Turkish diabetic patients
TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.27, sa.10, ss.873-878, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 10
- Basım Tarihi: 2011
- Doi Numarası: 10.1177/0748233711399317
- Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.873-878
- Anahtar Kelimeler: Serum PON1 activities, PON1 QR192 polymorphism, PON1 LM55 polymorphism, lipid peroxidation, diabetes, HIGH-DENSITY-LIPOPROTEIN, GENE POLYMORPHISMS, MOLECULAR-BASIS, ARYLESTERASE, POPULATION, MELLITUS, DISEASES, LIPIDS
- Ankara Üniversitesi Adresli: Evet
Özet
Paraoxonase (PON1) is a serum esterase responsible for the protection against xenobiotics toxicity such as paraoxon. Alterations in PON1 concentrations have been reported in a variety of diseases including diabetes mellitus (DM). It has been shown that the serum PON1 concentration and activity are decreased in patients with both type 1 and type 2 DM. This study aimed to investigate the lipid profiles and the relationship between PON1 activity and PON1, QR192 and LM55 polymorphisms in Turkish type 2 diabetic patients and non-diabetic control subjects. According to our results, RR variant had significantly higher PON activity than QQ and QR variants (p < 0.01) and LL variant had significantly higher PON activity than MM variant in both control and patient groups (p < 0.05). In conclusion, we found that PON1 192RR and 55LL genotypes are associated with higher PON activity than QQ and MM genotypes. This may be more protective to lipid peroxidation.