Potential Effect of Vortioxetine on Restless Leg Syndrome

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Alici Y. H., Kumcu M. K.

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, cilt.21, sa.3, ss.599-603, 2023 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.9758/cpn.22.1021
  • Dergi Adı: CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, Psycinfo
  • Sayfa Sayıları: ss.599-603
  • Anahtar Kelimeler: Restless legs syndrome, Vortioxetine, Depression, Anxiety, Serotonin and noradrenaline reuptake inhibitors, EKBOM DISEASE, DIAGNOSIS, PATHOPHYSIOLOGY, AUGMENTATION, DEPRESSION, DISORDERS, IRLSSG, IRON, RLS
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Üniversitesi Adresli: Evet

Özet

Restless legs syndrome (RLS) is a chronic progressive movement disorder characterized by abnormal sensations, espe-cially at rest and at night, as the need and urge to move the lower extremity. It has been reported that RLS severity and frequency increase in patients with anxiety and depression. It has been reported that serotonin-noradrenaline reup-take inhibitors such as venlafaxine and selective serotonin reuptake inhibitors such as citalopram, fluoxetine, paroxetine, and sertraline can cause RLS symptoms. No adverse effects of vortioxetine on RLS have been reported in the literature. In this case series, we report the effect of vortioxetine in patients with RLS with symptoms of depression and anxiety. In this case series, the effect of adding vortioxetine to treatment on RLS symptoms is reported in 7 patients (5 female). After the use of vortioxetine, 5 of 7 patients' symptoms regressed without the need to start a separate drug for primary movement disorder. In conclusion, we believe that studies should be conducted to investigate the efficacy of vortioxetine in the treatment of RLS. Therefore, randomized controlled studies are needed to determine the effect and safety of vortioxetine on RLS symptoms.